Aims and Scope
HIV Treatment and Care Services in Yemen: Implications Of Internal Country ConflictsMayada Faisal Nabih Mohammed and Sharifa Ezat Wan Puteh
The Open AIDS Journal, 2022; 16: e187461362210140.
Electronic Publication Date: December 21, 2022
Effect of Sickle Cell Trait on Human Immunodeficiency Virus Type 1 InfectionIheanyi Okpala, Chinwe Chukwuka, Seyed Nouraie, Sergei Nekhai, Chima Onwuka, Isa Hezekiah, Onochie Obodo, Deborah Maisamari, Kelechi Okereke, Ajake Oden, Yohanna Tanko, Chinedu Ezekekwu, Vivian Kwaghi, Cajetan Onyedum and Obiageli Nnodu
The Open AIDS Journal, 2022; 16: e187461362208150.
Electronic Publication Date: October 14, 2022
Utilization of ART Services Among People Living with HIV During the COVID-19 Pandemic: A Case of Kampala DistrictSendaula Emmanuel, Alupo Anne Loy and Ayella Patrickson
The Open AIDS Journal, 2022; 16: e187461362208170.
Electronic Publication Date: October 13, 2022
Coexistence of Competing Opportunistic Pathogens in Critically ill Patients with Advanced AIDS: A Case Report and Literature ReviewSeregey Voznesenskiy, Tatyana Ermak, Karl Emerole, Еlena Samotolkina, Polina Klimkova, Evgeniya Abramova and Galina Kozhevnikova
The Open AIDS Journal, 2022; 16: e187461362208040.
Electronic Publication Date: September 27, 2022
CLINICAL TRIAL STUDY
Changes in Coagulation and Platelet Reactivity in People with HIV-1 Switching Between Abacavir and TenofovirCamilla H. Drabe, Frederikke F. Rönsholt, Ditte M. Jakobsen, Sisse R. Ostrowski, Jan Gerstoft and Marie Helleberg
The Open AIDS Journal, 2022; 16: e187461362206200.
Electronic Publication Date: September 20, 2022
Association between Higher CD32a+CD4+ T Cell Count and Viral Load in the Peripheral Blood of HIV-infected PatientsNatalia A. Arsentieva, Oleg K. Batsunov, Alexander V. Semenov, Igor V. Kudryavtsev, Elena V. Esaulenko, Ekaterina V. Boeva, Alexey Y. Kovelenov, Areg A. Totolian
The significance of CD32a receptor expression in individuals infected with Human Immunodeficiency Virus (HIV) is currently unclear. Previously, B. Descours et al. (2017) concluded that in patients infected with HIV-1, CD32a is expressed on resting T cells that contain HIV DNA. According to the authors, these cells are reservoirs for inducible, replication-competent viruses. However, other studies have reported that CD32a expression is associated with activated T cells and is not a marker of HIV-1 reservoirs. The aims of this study were: to determine the significance of the CD32a marker in HIV infection, to assess its expression on T helper (Th) subpopulations in peripheral blood of HIV-infected individuals and to clarify the relationship between this expression and viral load.
For comparative analysis, the following groups were used: 27 HIV-infected patients; 11 individuals with Hepatitis C Virus (HCV) infection; 16 individuals with Hepatitis B Virus (HBV) infection; and 13 healthy donors. Peripheral blood served as the study material. The expression of CD32a receptor on Th cell subpopulations was assessed using flow cytometry. Nonparametric statistical methods were used for data analysis.
It was found that relative CD32a+ Th cell counts in HIV-infected individuals significantly exceeded corresponding values in other groups: healthy individuals (p<0.0001), those with HCV infection (p=0.0008) and those with HBV infection (p <0.0001). Among the Th subpopulations in HIV-infected patients, the CD32a receptor was predominantly expressed on Th1 cells (p<0.0001) and Th2 cells (p<0.0001), compared with Th17. We found a strong, direct correlation (r=0.78; p<0.0001) between viral load and CD32a+CD4+ T cell count in peripheral blood of HIV-infected individuals.
Thus, our results provide evidence that the CD32a receptor can serve as a marker of HIV infection, and its expression depends on viral load. Clinical material was used here, for the first time, to show that CD32a is predominantly expressed on Th1 and Th2 cells.
July 13, 2021
- May 23, 2020
Preclinical Assessment of a Cartridge-Based Flow-Through Assay for Determination of Adult CD4 T-Cell CountMay 31, 2019
Immunologic Restoration of People Living with Human Immunodeficiency Virus on Highly Active Anti-retroviral Therapy in Ethiopia: The Focus of Chronic Non-Communicable Disease Co-MorbiditiesApril 30, 2019
Inconsistent Use of Condom in Italian HIV-Serodiscordant Heterosexual Couples as Revealed by the Detection of Y Chromosomal (Yc) DNA in Vaginal Swabs