Aims and Scope
Public Awareness and Stigmatizing Attitudes toward People Living with Human Immunodeficiency Virus Acquired Immune Deficiency Syndrome in Saudi ArabiaMarwan J. Alwazzeh, Abdullah H. Kabbani, Muhannad A. Alghamdi, Khalid I. Alharbi, Abdullah A. Qoqandi, Abdulrazaq I. Alsomali and Jose Ramon Fiore
The Open AIDS Journal, 2023; 17: e187461362303080.
Electronic Publication Date: April 27, 2023
Short-term Effect of Training in Increasing Midwives’ Knowledge, Attitudes, and Practices Related to HIV and AIDS PreventionZahroh Shaluhiyah, Antono Suryoputro and Delita Septialti
The Open AIDS Journal, 2023; 17: e187461362301240.
Electronic Publication Date: March 03, 2023
High Prevalence of Lower Extremity Medial Arterial Calcification in HIV-infected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional StudyKlaudija Višković, Annibale Marinelli, Katrin Nedeljko, Petra Povalej Bržan, Nikolina Bogdanić and Josip Begovac
The Open AIDS Journal, 2023; 17: e187461362212230.
Electronic Publication Date: January 16, 2023
Association between Higher CD32a+CD4+ T Cell Count and Viral Load in the Peripheral Blood of HIV-infected PatientsNatalia A. Arsentieva, Oleg K. Batsunov, Alexander V. Semenov, Igor V. Kudryavtsev, Elena V. Esaulenko, Ekaterina V. Boeva, Alexey Y. Kovelenov, Areg A. Totolian
The significance of CD32a receptor expression in individuals infected with Human Immunodeficiency Virus (HIV) is currently unclear. Previously, B. Descours et al. (2017) concluded that in patients infected with HIV-1, CD32a is expressed on resting T cells that contain HIV DNA. According to the authors, these cells are reservoirs for inducible, replication-competent viruses. However, other studies have reported that CD32a expression is associated with activated T cells and is not a marker of HIV-1 reservoirs. The aims of this study were: to determine the significance of the CD32a marker in HIV infection, to assess its expression on T helper (Th) subpopulations in peripheral blood of HIV-infected individuals and to clarify the relationship between this expression and viral load.
For comparative analysis, the following groups were used: 27 HIV-infected patients; 11 individuals with Hepatitis C Virus (HCV) infection; 16 individuals with Hepatitis B Virus (HBV) infection; and 13 healthy donors. Peripheral blood served as the study material. The expression of CD32a receptor on Th cell subpopulations was assessed using flow cytometry. Nonparametric statistical methods were used for data analysis.
It was found that relative CD32a+ Th cell counts in HIV-infected individuals significantly exceeded corresponding values in other groups: healthy individuals (p<0.0001), those with HCV infection (p=0.0008) and those with HBV infection (p <0.0001). Among the Th subpopulations in HIV-infected patients, the CD32a receptor was predominantly expressed on Th1 cells (p<0.0001) and Th2 cells (p<0.0001), compared with Th17. We found a strong, direct correlation (r=0.78; p<0.0001) between viral load and CD32a+CD4+ T cell count in peripheral blood of HIV-infected individuals.
Thus, our results provide evidence that the CD32a receptor can serve as a marker of HIV infection, and its expression depends on viral load. Clinical material was used here, for the first time, to show that CD32a is predominantly expressed on Th1 and Th2 cells.
July 13, 2021
- May 23, 2020
Preclinical Assessment of a Cartridge-Based Flow-Through Assay for Determination of Adult CD4 T-Cell CountMay 31, 2019
Immunologic Restoration of People Living with Human Immunodeficiency Virus on Highly Active Anti-retroviral Therapy in Ethiopia: The Focus of Chronic Non-Communicable Disease Co-MorbiditiesApril 30, 2019
Inconsistent Use of Condom in Italian HIV-Serodiscordant Heterosexual Couples as Revealed by the Detection of Y Chromosomal (Yc) DNA in Vaginal Swabs