Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women

Rivera-Morales, Lydia Guadalupe; Lopez-Guillen, Paulo; Vazquez-Guillen, Jose Manuel; Palacios-Saucedo, Gerardo C; Rosas-Taraco, Adrian G; Ramirez-Pineda, Antonio; Amaya-Garcia, Patricia Irene; Rodriguez-Padilla, Cristina

Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women

Lydia Guadalupe Rivera-Morales^{*, 1}, Paulo Lopez-Guillen², Jose Manuel Vazquez-Guillen¹, Gerardo C Palacios-Saucedo³, Adrian G Rosas-Taraco⁴, Antonio Ramirez-Pineda¹, Patricia Irene Amaya-Garcia¹, Cristina Rodriguez-Padilla¹

¹ Laboratorio de Inmunologia y Virologia; Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Mexico

² Unidad de Infectologia “Dr. Juan I. Menchaca”. Hospital General Regional No. 45. Instituto Mexicano del Seguro Social, Jalisco, Mexico

³ Departamento de Pediatria, Unidad Medica de Alta Especialidad No. 25 and Centro de Investigacion Biomedica del Noreste, Instituto Mexicano del Seguro Social, Nuevo Leon, Mexico

⁴ Departamento de Inmunologia del Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Mexico

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 239
Last Page: 244
Publisher ID: TOAIDJ-6-239
DOI: 10.2174/1874613601206010239

Article History:

Received Date: 6/9/2011
Revision Received Date: 25/11/2011
Acceptance Date: 12/4/2012
Electronic publication date: 5/10/2012
Collection year: 2012

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© Rivera-Morales et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Av. Pedro de Alba y Manuel L. Barragan s/n, Ciudad Universitaria, San Nicolas de los Garza, Nuevo Leon, C.P. 66451, Mexico; Tel: (52 81) 83294115; Fax: (52 81) 83524212; E-mail: lydia_rivera_@hotmail.com

Background:

A number of studies have demonstrated that receptor and co-receptor expression levels which may affect viral entry, promoting cervical HIV infection. The aim was to evaluate the expression levels of CCR5, CXCR4and DC-SIGN mRNA in a sample of heterosexually HIV infected Mexican women.

Methods:

We enrolled twenty-six HIV heterosexual infected women attending a local infectious diseases medical unit.RNA was isolated from the cervix and gene expression analysis was performed using real-time PCR.

Results:

Expression rates for mRNA of CCR5 (median 1.82; range 0.003–2934) were higher than those observed for CXCR4 (0.79; 0.0061–3312) and DC-SIGN (0.33; 0.006–532) receptors (p < 0.05). A high correlation was found between the mRNA expression levels of these three receptors (rs = 0.52 to 0.85, p < 0.01).

Conclusion:

Levels of expression of the tested chemokine receptors in the cervix are different from each other and alsovary from woman to woman, and seem to support the suggestion that chemokine receptor expression in genital tissues may be playing a role in the HIV transmission.

Keywords:: AIDS, HIV-1, Mucosae, CCR5, CXCR4, DC-SIGN..

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RESEARCH ARTICLE

Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women

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