Meta-Analysis of The Prevalence of Genital Infections Among Hiv Carriers and Uninfected Women
Ana Paula Ferreira Costa1, #, *, Marcos Gonzaga dos Santos2, #, Ayane Cristine Alves Sarmento3, Pedro Henrique Alcântara da Silva4, Guilherme Maranhão Chaves3, Janaina Cristiana de Oliveira Crispim2, Ana Katherine Gonçalves4, Ricardo Ney Oliveira Cobucci5
Identifiers and Pagination:Year: 2018
First Page: 136
Last Page: 149
Publisher Id: TOAIDJ-12-136
Article History:Received Date: 22/4/2018
Revision Received Date: 24/8/2018
Acceptance Date: 6/9/2018
Electronic publication date: 30/10/2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background & Aim:
The risk factors in acquiring genital co-infections associated with HIV infection still present many questions. We conducted a systematic review and meta-analysis to compare the prevalence of genital infection among HIV-infected and uninfected women.
We searched PubMed, Web of Science, Scopus and Scielo for the relevant studies up until October 2017. Data were collected from the included studies and methodologically assessed. Odds ratios (OR) and 95% confidence intervals (CI) were pooled using fixed or random-effects models.
Thirty-six articles involving 23,863 women with retroviruses were included. HIV-infected women were significantly more diagnosed with the following genital infections: Herpes simplex virus type 2 (HSV-2) (OR 3.70; 95% CI: 2.42–5.65), Neisseria gonorrhoeae (GC) (OR 4.18; 95% CI: 2.15-8.13), Chlamydia trachomatis (CT) (OR 2.25; 95% CI: 1.20-4.23) and Human papillomavirus (HPV) (OR 3.99, 95% CI: 3.35-4.75). There was no significant difference in the prevalence of bacterial vaginosis (OR 1.09; 95% CI: 0.91-1.30), Candida sp. (OR 1.51; 95% CI: 0.71-3.25), Treponema pallidum (OR 1.56; 95% CI: 1.00-2.45) and Trichomonas vaginalis (OR 1.00; 95% CI: 0.47-2.15).
The prevalence of HPV, HSV-2, GC and CT genital infection was significantly higher among HIV-positive women.