Association Between Health-Related Quality of Life and Physical Functioning in Antiretroviral-Naive HIV-Infected Patients

Ana Paula Lédo1, #, Indira Rodriguez-Prieto1, #, Liliane Lins1, Mansueto Gomes Neto2, Carlos Brites3, *
1 School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
2 Health Science Institute, Federal University of Bahia, Brazil
3 Research Laboratory of Infectious Diseases, Edgard Santos Federal University Hospital, Salvador, Bahia, Brazil

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© 2018 Lédo et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the LAPI - Research Laboratory of Infectious Diseases, Edgard Santos Federal University Hospital, Rua Augusto Viana, S/n, Canela, Salvador, Bahia, Brazil, CEP-40110060, Tel: 55 71 3283-8126; E-mail:

# These authors have equally contributed for this work



Poor functional status can significantly affect Health-Related Quality of Life (HRQoL) of HIV patients. However, there is scarce information on the functional profile of such patients before starting antiretroviral therapy (ART).


To estimate the association between health-related quality of life and physical functioning in Antiretroviral-Naive HIV-infected patients.


We conducted a cross-sectional study with HIV-infected patients older than 18 years, and naïve to antiretroviral therapy. The patients were evaluated for functional profile by pulmonary function (forced vital capacity, forced expiratory volume at one second, and Tiffeneau index), handgrip strength, and six-minute walk test in a cross-sectional study. HRQoL was evaluated by the 36-Item Short-Form Health Survey and its Physical (PCS) and Mental (MCS) Component Summaries. Multiple linear regression analyses were used to evaluate the association of predictor variables with PCS and MCS scores.


We found lower HRQoL among females patients, with far below average impairment of mental health component. Both male and female patients presented lower 6MWD function test values. Patients with dynapenia were older than patients without it, presented lower PCS mean score, lower family income, poor 6 MWD function test, lower FVC, and lower FEV1 t. Multivariable logistic regression analyses showed that Grip Strength, age and family income were predictor variables for Physical component of HRQoL. Female gender and smoking habit were predictive for the mental component of HRQoL.


HRQoL in HIV, drug-naïve patients is predicted by level of dynapenia, smoking, income and gender. Therefore, lifestyle changes and active exercising can help to improve HRQoL in such patients.

Keywords: HIV infection, Acquired Immunodeficiency Syndrome, Health-related quality of life, HRQOL, Life Quality, Physical Conditioning Human.