Sero-prevalence and Correlates of Hepatitis B and C Co-infection Among HIV-infected Individuals in Two Regional Hospitals in Cameroon



Henry Namme Luma1, 2, *, Servais Albert Fiacre Bagnaka Eloumou1, 3, Domin Sone Majunda Ekaney4, Fernando Kemta Lekpa1, Olivier Donfack-Sontsa5, Bertrand Hugo Mbatchou Ngahane1, 3, Yacouba Njankouo Mapoure1, 3
1 Internal Medicine Unit, Douala General Hospital, Douala, Cameroon
2 Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon
3 Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon
4 Faculty of Health Sciences, University of Buea, Buea, Cameroon
5 London School of Hygiene and Tropical Medicine, University of London, UK


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© Luma et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Douala General Hospital, P.0. Box 4856, Douala, Cameroon; Tel: 237,699960059; Fax: +237 243 37 01 46; E-mail: hnluma@yahoo.com


Abstract

Background:

Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive.

Objective:

We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals.

Methods:

A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres. Data was collected using a structured questionnaire. Blood samples were collected to screen for Hepatitis with HBsAg and anti HCV antibody rapid immunochromatographic test kits. Correlates of hepatitis were investigated by logistic regression. STATA was used for data analysis.

Results:

We included 833 HIV/AIDS patients,78.8% (657) were female. Mean age was 44(SD 11) years. Prevalence of Hepatitis in general (total of two viral markers tested) was 8.9% (74/833), with 6.1% for HBsAg and 2.8% for Anti-HCV antibodies. From multivariate analysis, the likelihood of having hepatitis was independently increased by a history of surgical interventions [OR: 1.82(1.06-3.14)], and of sexually transmitted infections [OR: 2.20(1.04-4.67)].

Conclusion:

Almost one in ten participants with HIV/AIDS attending the BRH and LRH tested positive for either HBsAg or anti HCV antibodies. Screening for HBV and HCV should therefore be integrated to the existing guidelines in Cameroon as it can influence management. More studies are needed to evaluate the extent of liver disease and magnitude of HIV suppression in hepatitis and HIV coinfection in this setting.

Keywords: Cameroon, Correlates, HBV, HCV, HIV/AIDS, Prevalence, Screening.