A Matter of Perspective: Comparison of the Characteristics of Persons with HIV Infection in the United States from the HIV Outpatient Study, Medical Monitoring Project, and National HIV Surveillance System



Kate Buchacz*, 1, Emma L. Frazier1, H. Irene Hall1, Rachel Hart2, Ping Huang1, Dana Franklin2, Xiaohong Hu1, Frank J. Palella3, Joan S. Chmiel3, Richard M. Novak4, Kathy Wood2, Bienvenido Yangco5, Carl Armon2, John T. Brooks1, Jacek Skarbinski1
1 Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
2 Cerner Corporation, Kansas City, MO, USA
3 Northwestern University, Chicago, IL, USA
4 University of Illinois, Chicago, IL, USA
5 Infectious Disease Research Institute, Tampa, FL, USA


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© Buchacz et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS E-45, Atlanta, GA 30329. USA; Tel: (404) 639-5167; E-mail: acu7@cdc.gov


Abstract

Comparative analyses of the characteristics of persons living with HIV infection (PLWH) in the United States (US) captured in surveillance and other observational databases are few. To explore potential joint data use to guide HIV treatment and prevention in the US, we examined three CDC-funded data sources in 2012: the HIV Outpatient Study (HOPS), a multisite longitudinal cohort; the Medical Monitoring Project (MMP), a probability sample of PLWH receiving medical care; and the National HIV Surveillance System (NHSS), a surveillance system of all PLWH. Overall, data from 1,697 HOPS, 4,901 MMP, and 865,102 NHSS PLWH were analyzed. Compared with the MMP population, HOPS participants were more likely to be older, non-Hispanic/Latino white, not using injection drugs, insured, diagnosed with HIV before 2009, prescribed antiretroviral therapy, and to have most recent CD4+ T-lymphocyte cell count ≥500 cells/mm3 and most recent viral load test<2 00 copies/mL. The MMP population was demographically similar to all PLWH in NHSS, except it tended to be slightly older, HIV diagnosed more recently, and to have AIDS. Our comparative results provide an essential first step for combined epidemiologic data analyses to inform HIV care and prevention for PLWH in the US.

Keywords: AIDS, cohort, epidemiology, HIV, observational study, surveillance, United States.