Do Men who have Sex with Men (MSM) in the United States Understand that HIV Serodiscordance is Possible?



Bradley H. Wagenaar1, Kristina L. Grabbe2, Rob Stephenson3, Christine M. Khosropour1, Patrick S. Sullivan*, 1
1 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
2 Capacity Building Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
3 Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA


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© Wagenaar et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the 1518 Clifton Road, N. E., Room 438, Atlanta, GA 30322, USA; Tel: 404-727-2038; E-mail: pssulli@emory.edu


Abstract

Background

Little is currently known about the extent to which US MSM understand the possibility that a long-term sex partner can have an HIV status different than one’s own status. This information is important in the adaptation of Couples Voluntary HIV Counseling and Testing (CVCT) for US MSM.

Methods

428 US MSM completed an online survey using MySpace.com from March-April, 2009.

Results

Of 426 MSM with complete data, 21.1% (90) were not definitively aware that serodiscordance is possible. Factors associated with a lack of understanding that serodiscordance is possible were: never having tested for HIV (OR: 2.0; CI: 1.1, 3.8), compared to testing 0-6 months previously and having a high school education or less (OR: 2.2; CI: 1.1, 4.5), compared to men who had completed at least some college.

Conclusions

A large proportion of young, internet-using MSM in the United States may not understand that HIV serodiscordance is possible within sexual partnerships. Based on these results, we recommend that CVCT provided to male couples in the United States should include education on HIV serodiscordance.

Keywords: : CVCT, HIV knowledge, HIV serodiscordance, HIV/AIDS, epidemiology..



INTRODUCTION

Men who have sex with men (MSM) continue to represent the majority of all new HIV diagnoses in the United States (US); developing and testing interventions to serve MSM is a high priority for HIV prevention [1,2]. Couples Voluntary Counseling and Testing (CVCT) is an African testing service that has been recently adapted for use with US male couples who have also expressed high levels of hypothetical willingness to participate in CVCT [3,4]. The African CVCT intervention includes an educational component to help couples understand that HIV serodiscordance is possible – that is, that one partner may be HIV-positive while the other is HIV-negative. It is not clear whether MSM in the US would also benefit from education about the possibility of HIV serodiscordance in the adapted CVCT intervention for MSM. Limited available data suggest that MSM tend to assume HIV partner concordance [5,6]; MSM are more likely to engage in unprotected anal intercourse (UAI) with partners who are perceived to share the same HIV serostatus, compared to those who are HIV discordant or whose status they do not know [7,8].

METHODS

Data were from the 3-month follow-up time point of an online HIV prevention research study for US MSM. Methods have been previously reported [9]. Briefly, MSM were recruited online from MySpace.com from March-April, 2009 in the US. Men who were white, black, or Hispanic and who consented to prospective follow-up were invited to participate in a 3-month follow-up survey July-August, 2009.

In addition to demographic and behavioral information, the survey collected data on men’s understanding of the possibility of HIV serodiscordance, measured using responses to the statement: “in a couple that has been having sex for several years, if one partner is HIV-negative the other partner is also HIV-negative.” Men who responded “false” were considered to understand that serodiscordance is possible; others were considered not to understand. Using logistic regression in SAS 9.3 (Cary, NC), we calculated crude odds ratios and 95% confidence intervals (CI) for the associations of understanding that serodiscordance is possible with selected demographic characteristics and sexual risk behaviors. Two-tailed Wald tests and an alpha level of 0.05 were used for significance testing.

RESULTS

From 428 total survey respondents, we excluded one man with missing data and one man responding “prefer not to answer” to the serodiscordance question. Most respondents were between 18-24 years of age, and over 75% had a main male sex partner in the last 12 months (Table 1). Over 70% of respondents reported UAI in the last 12 months. nearly half had received and HIV test in the last 12 months and about a quarter had never been tested for HIV. Over 30% did not know their most recent male sex partner’s HIV status.

Table 1.

Characteristics Associated with Not Understanding that HIV Serodiscordance is Possible Among 426a US MSM, 2009


Characteristics Sample Totals
n (%) Unless Notedb
False
n (%)
True/Don't Know
n (%)c
Unadjusted OR
(95% CI)
Total 426 (100) 336 (78.9) 90 (21.1)
Race/Ethnicity
   Non-Hispanic White 203 (47.7) 162 (79.8) 41 (20.2) 1 (reference)
   Non-Hispanic Black 61 (14.3) 45 (73.8) 16 (26.2) 1.4 (0.72, 2.7)
   Hispanic 162 (38.0) 129 (79.6) 33 (20.4) 1.0 (0.61, 1.7)
Age 22 (median), 6 (IQR)
   18-24 284 (66.7) 224 (78.9) 60 (21.1) 1 (reference)
   25-29 87 (20.4) 71 (81.6) 16 (18.4) 0.84 (0.46, 1.6)
   Over 30 55 (12.9) 41 (74.6) 14 (25.5) 1.3 (0.65, 2.5)
Education
   College, post graduate, or professional school 88 (20.7) 76 (86.4) 12 (13.6) 1 (reference)
   Some college, associate's or technical degree 206 (48.4) 162 (78.6) 44 (21.4) 1.7 (0.86, 3.4)
   High school or less 129 (30.3) 98 (74.2) 34 (25.8) 2.2 (1.1, 4.5)*
   Missing 3 (0.70) 2 (66.7) 1 (33.3)
Region
   Midwest 67 (15.7) 54 (80.6) 13 (19.4) 1 (reference)
   North 66 (15.5) 50 (75.8) 16 (24.2) 1.3 (0.58, 3.0)
   South 133 (31.2) 107 (80.5) 26 (19.5) 1.0 (0.48, 2.1)
   West 141 (33.1) 112 (79.4) 29 (20.6) 1.1 (0.52, 2.2)
   Missing 19 (4.5) 13 (68.4) 6 (31.6)
Had a main male sex partner in last 12 months
   No 103 (24.2) 78 (75.7) 25 (24.3) 1 (reference)
   Yes 323 (75.8) 258 (79.9) 65 (20.1) 0.79 (0.46, 1.3)
Most recent male sex partner's HIV status
   Negative 266 (62.4) 212 (79.7) 54 (20.3) 1 (reference)
   Positive 17 (4.0) 13 (76.5) 4 (23.5) 1.2 (0.38, 3.9)
   Unknown 143 (33.6) 111 (77.6) 32 (22.4) 1.1 (0.69, 1.9)
Had unprotected anal intercourse in last 12 months
   No 121 (28.4) 98 (81.0) 23 (19.0) 1 (reference)
   Yes 305 (71.6) 238 (78.0) 67 (22.0) 1.2 (0.71, 2.0)
Number of male sex partners in last 12 months 4 (median), 5 (IQR)
   1 83 (19.5) 66 (79.5) 17 (20.5) 1 (reference)
   2 - 3 115 (27.0) 85 (73.9) 30 (26.1) 1.4 (0.70, 2.7)
   4 - 7 123 (28.9) 101 (82.1) 22 (17.9) 0.85 (0.42, 1.7)
   >7 105 (24.6) 84 (80.0) 21 (20.0) 0.97 (0.47, 2.0)
Time since last HIV test
   0-6 months 112 (26.3) 90 (80.4) 22 (19.6) 1 (reference)
   7-12 months 84 (19.7) 71 (84.5) 13 (15.5) 0.75 (0.35, 1.6)
   >12 months 91 (21.4) 74 (81.3) 17 (18.7) 0.94 (0.47, 1.9)
   Never tested 100 (23.5) 67 (67.0) 33 (33.0) 2.0 (1.1, 3.8)*
   Un known 39 (9.2) 34 (87.2) 5 (12.8) 0.60 (0.21, 1.7)

P < .05 (Wald X2)

From 428 total respondents, excludes one man with missing data and one man responding “prefer not to answer” regarding the statement: “In a couple that has been having sex for several years, if one partner is HIV-negative the other partner is HIV-negative.”

Percentages in this column reflect column percentages. For example, 47.7% of our sample was of Non-Hispanic White race/ethnicity. All other columns are row percentages pertaining to percent responding “correctly” or “incorrectly” to the serodiscordance question.

Includes 49 men responding “true” and 41 responding “don’t know” regarding the statement: “In a couple that has been having sex for several years, if one partner is HIV-negative the other partner is HIV-negative.”

Abbreviations: OR, Odds Ratio; HIV, Human immunodeficiency virus; IQR, Interquartile range.

Of 426 men included in the analysis, 21.1% (90) of MSM were not aware that serodiscordance is possible: 11.5 percent (49) responded “true” and 9.6% (41) responded “I don’t know” to the question about serodiscordance. The odds of not understanding that serodiscordance is possible were 2.0 (CI: 1.1, 3.8) times as high for men who had never tested for HIV, compared to the odds for men who had tested for HIV 0-6 months previously. Additionally, the odds of not understanding that serodiscordance is possible were 2.2 (CI: 1.1-4.5) times as high among men with a high school education or less, compared to the odds for men who had completed at least some college.

DISCUSSION

A substantial proportion of young, internet-using MSM in the United States may not understand that HIV serodiscordance is possible within sexual partnerships. Lack of understanding may occur especially among men not previously tested for HIV and those with less educational attainment. These same factors have been recently reported to be associated with lower levels of general HIV knowledge [10].

We recognize several important limitations to our work. First, we were limited to a single item for this assessment, and the measure is imperfect. We considered respondents who answered “I don’t know” to not be aware of the possibility of serodiscordance. However, even if we only considered those who endorsed the item as true as not being aware of the possibility of serodiscordance, our primary conclusion - that an important proportion of young MSM are not definitively certain that serodiscordance is possible - is still valid. We also acknowledge that our sample is not representative of all US MSM, or all internet-using MSM.

Based on these results, we recommend that CVCT provided to male couples in the United States should include education on HIV serodiscordance. Since approximately one in six MSM who had been previously tested for HIV also did not recognize the possibility of serodiscordance, this concept might also be important to include in general HIV/AIDS educational interventions and standard prevention counseling with individuals receiving HIV counseling and testing.

CONFLICT OF INTEREST

The authors confirm that this article content has no conflict of interest.

ACKNOWLEDGEMENTS

The authors would like to thank Nicole Luisi for her expert support and data management.

This work was supported by the Center for AIDS Research at Emory University (P30 AI050409) and the National Institute on Minority Health and Health Disparities (RC1MD004370).

DISCLAIMER

The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention.

REFERENCES

[1] Prejean J, Song R, Hernandez A, et al. Estimated HIV indicence in the United States. 2006-2009 PLoS ONE 2011; 6(8): e17502.
[2] Sullivan PS, Carballo-Dieguez A, Coates T, et al. Successes and challenges of HIV prevention in men who have sex with men.[Research Support. N..H..Extramural Research Support., Non-U.S. Gov't]. Lancet 2012; 380(9839): 388-99.
[3] Stephenson R, Sullivan PS, Salazar LF, Gratzer B, Allen S, Seelbach E. Attitudes towards couples-based HIV testing among MSM in three US cities. AIDS Behav 2011; 15 Suppl 1: S80-7.
[4] Wagenaar BH, Christiansen-Lindquist L, Khosropour C, et al. Willingness of US men who have sex with men (MSM) to participate in couples HIV voluntary counseling and testing (CVCT). PLoS ONE 2012; 7(8): e42953.
[5] Parsons JT, Severino J, Nanin J, et al. Positive. negaive.unknown assumptions of HIV status among HIV positive men who have sex with men AIDS Educ Prev 2006; 18(2): 139-49.
[6] Niccolai LM, Farley TA, Ayoub MA, Magnus M, Kissinger PJ. HIV-infected persons' knowledge of their sexual partners' HIV status. AIDS Educ Prev 2002; 14(3): 183-9.
[7] Golden MR, Brewer DD, Kurth A, Holmes KK, Handsfield HH. Importance of sex partner HIV status in HIV risk asessment among men who have sex with men. J Acquir Immune Defic Syndr 2004; 36(2): 734-42.
[8] Hoff CC, Stall R, Paul J, et al. Differences in sexual behavior among HIV discordant and concordant gay men in primary relationships. J Acquir Immune Defic Syndr 1997; 4(1): 72-8.
[9] Sullivan PS, Khosropour CM, Luisi N, et al. Bias in online recruitment and retention of racial and ethnic minority men who have sex with men. J Med Internet Res 2011; 3(2): e38.
[10] Wagenaar BH, Sullivan PS, Stephenson R. HIV knowledge and associated factors among internet-using men who have sex with men (MSM) in South Africa and the United States. PLoS ONE 2012; (3): e32915.