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RESEARCH ARTICLE

Plasma Level of Soluble ST2 in Chronically Infected HIV-1 Patients with Suppressed Viremia

Mehwish Younas1 Christina Psomas1 , 2 Vikram Mehraj3 Renaud Cezar4 Pierre Portales5 Edouard Tuaillon6 Adeline Guigues1 Jacques Reynes2 , 7 , 8 Pierre Corbeau1 , 4 , 8 , * Open Modal , † Open Modal Jean-Pierre Routy3 , 9 , † Open Modal Authors Info & Affiliations
The Open AIDS Journal • 26 Apr 2017 • RESEARCH ARTICLE • DOI: 10.2174/1874613601711010032

Abstract

Introduction:

Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.

Observation:

Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.

Results:

Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.

Keywords: Interleukin-33, Plasma, HIV, Viremia, Cardiovascular, Translocation.
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