Plasma Level of Soluble ST2 in Chronically Infected HIV-1 Patients with Suppressed Viremia



Mehwish Younas1, Christina Psomas1, 2, Vikram Mehraj3, Renaud Cezar4, Pierre Portales5, Edouard Tuaillon6, Adeline Guigues1, Jacques Reynes2, 7, 8, Pierre Corbeau1, 4, 8, *, , Jean-Pierre Routy3, 9,
1 Institute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France,
2 Infectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, France,
3 Research Institute and Chronic Viral Illness Service of the McGill University Health Center, Montréal, Québec, Canada
4 Immunology Department, University Hospital, Place du Pr Debré, 30029 Nîmes cedex, France,
5 Immunology Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, France,
6 Microbiology Department, University Hospital, 371 Av. du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France,
7 UMI 233, IRD-Montpellier I University, 911 avenue Agropolis, 34294 Montpellier cedex 5, France,
8 Montpellier I University, 5 Boulevard Henri IV, 34967 Montpellier cedex 2, France,
9 Division of Hematology, McGill University Health Center, Montréal, Québec, Canada


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© 2017 Younas et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Professor Pierre Corbeau, Institut de Génétique Humaine CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France, Tel: +33 4 34 35 99 32, Fax: +33 4 34 35 99 01, E-mail: pierre.corbeau@igh.cnrs.fr

† P.C. and J.-P.R. contributed equally to this work.



Abstract

Introduction:

Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.

Observation:

Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.

Results:

Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.

Keywords: Interleukin-33, Plasma, HIV, Viremia, Cardiovascular, Translocation.