Coexistence of Competing Opportunistic Pathogens in Critically ill Patients with Advanced AIDS: A Case Report and Literature Review

Voznesenskiy, Seregey; Ermak, Tatyana; Emerole, Karl; Samotolkina, Еlena; Klimkova, Polina; Abramova, Evgeniya; Kozhevnikova, Galina

Coexistence of Competing Opportunistic Pathogens in Critically ill Patients with Advanced AIDS: A Case Report and Literature Review

Seregey Voznesenskiy¹, Tatyana Ermak², Karl Emerole^{1, *}, Еlena Samotolkina³, Polina Klimkova³, Evgeniya Abramova³, Galina Kozhevnikova¹

¹ Department of Infections Diseases, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia

² Central Research Institute of Epidemiology, Moscow, Russia

³ Infectious Diseases Clinical Hospital No 2 Moscow, Russia

Article Information

Identifiers and Pagination:

Year: 2022
Volume: 16
E-location ID: e187461362208040
Publisher ID: e187461362208040
DOI: 10.2174/18746136-v16-e2208040

Article History:

Received Date: 15/3/2022
Revision Received Date: 15/4/2022
Acceptance Date: 20/5/2022
Electronic publication date: 27/09/2022
Collection year: 2022

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© 2022 Voznesenskiy et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at Department of Infections Diseases, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; E-mail: kamerole@yahoo.com

Introduction:

Opportunistic infections (OIs) are the leading causes of morbidity and mortality among HIV-infected individuals. The incidence of OIs is greater in antiretroviral treatment (ART) naive patients. As of 30 June 2021, 28.2 (73%) people with HIV/AIDS (PLWHA) were accessing antiretroviral therapy (ART) globally, leaving the remaining 27% PLWHA without ART at risk for OIs. Multiple opportunistic infections are caused due to the coexistence of competing opportunistic pathogens that confound clinical manifestations, investigative procedures, and management protocols.

Case Presentation:

In this report, we describe the case of a critically ill HIV female patient admitted to the ICU. The patient was diagnosed with multiple opportunistic infections and subsequently died after her illness progressed. Due to the paucity of information on the subject, we conducted a retrospective study of 1440 case records of HIV/AIDS critically ill patients to determine the incidence and spectrum of multiple opportunistic infections. We performed a review of the available medical literature relevant to the subject.

Conclusion:

Knowledge of such events would guide and enhance the physician's diagnostic and management strategies, especially in resource limited regions.

Keywords: HIV, Advanced AIDS, Opportunistic pathogens, Opportunistic infections, Coexistence, Intensive care unit.

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CASE REPORT

Coexistence of Competing Opportunistic Pathogens in Critically ill Patients with Advanced AIDS: A Case Report and Literature Review

Article Information

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Article History:

Article Metrics

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Total Statistics:

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Abstract

Introduction:

Case Presentation:

Conclusion:

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About the Editor

About the Journal

The Open AIDS Journal

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